The I-STEM Resource Network is a partnership of public and private higher education institutions, K-12 schools, businesses, and government, hosted by Purdue University. I-STEM was started in 2006 as a collaboration among 18 institutions of higher education in 10 regions throughout Indiana. I-STEM includes committees comprised of educational content experts and practitioners who come together to design and employ programs to address STEM issues. I-STEM supports K–12 teachers and education leaders working to implement high academic standards towards STEM literacy for all students. It also provides Indiana education leaders with new knowledge about teaching and learning.

I-STEM has many great corporate partners such as Lilly, Biocrossroads, Dow AgroSciences, OrthoWorx, Cook Medical, Cummins, Roche Diagnostics, Crane Naval Surface Weapons Center, and Rolls Royce. I-STEM welcomes partnerships with all the STEM businesses in Indiana.

I-STEM is funded by the Lilly Endowment, the Eli Lilly Company Foundation, Biocrossroads, the Indiana Commission for Higher Education, and the Indiana Department of Education, with support from Purdue University.